Recent Advance in Melanogenesis
نویسندگان
چکیده
Solar radiation induces both acute and chronic responses in the skin. Sun burn, sun tan, generation of reactive oxygen species and immunosuppression are acute responses. Wrinkles, lentigines, post-inflammatory pigmentation are chronic damages. According to one study done in Japan, it was found out that the annual ultraviolet dose received by people living in Kagoshima was 1.6 times higher than those living in Akita, noting that their latitudes were 32 degree North and 40 degree North respectively. The amount of freckles in the face of a 40-year-old lady living in Kagoshima is the same as a 60-year-old lady in Akita. It is obvious that UV light plays an important role in melanogenesis. DNA fragments produced after UV exposure also stimulate melanogenesis. It is estimated that one hour of sun exposure at noon in a locality like Hong Kong may result in as much as 1,000,000 DNA damages. Cytokines, alpha-melanocyte stimulating hormone (alpha-MSH) and Vitamin D are reported to be factors important in UV-melanogenesis.
منابع مشابه
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